CaM kinase II inhibitor TFA salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Autocamtide-2-Related Inhibitory Peptide 是一种高度特异且有效的 CaMKII 抑制剂，IC50 为 40 nM。 研究发现 Autocamtide-2-Related Inhibitory Peptide (TFA) 是一种有效的 CaM-kinase II 抑制剂，IC50 为40 nM，在存在或不存在 Ca2+/钙调蛋白的情况下均具有活性。

Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.It is found that Autocamtide-2-related inhibitory peptide (TFA) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93, respectively, under the assay condition used.

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Autocamtide-2-related inhibitory peptide (TFA)

Endocrinology/Hormones

CaMK

CaMKII

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1611.76

C66H126N22O21F3

>98% (HPLC)

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C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O.FC(F)(F)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years